Ecogenetics: Genetic predisposition to toxic effects of chemicals

Rok: 1991
ISBN: 9780412392900
OKCZID: 110483278

Citace (dle ČSN ISO 690):
GRANDJEAN, Philippe, ed. Ecogenetics: genetic predisposition to the toxic effects of chemicals. 1st ed. London: Published on behalf of the World Health Organization, Regional Office for Europe by Chapman & Hall, c1991. xiv, 288 s.

Anotace

Human beings vary in their sensitivity to environmental chemicals. Some people are particularly sensitive to certain chemical compounds and may, therefore, develop adverse effects as a result of exposures that are otherwise considered safe. Considerable variation in susceptibility may be determined by inherited patterns of metabolism. Research in several fields is now beginning to uncover the mechanisms and the significance of such inherited hypersusceptibility to environmental chemicals. This evidence will be of crucial importance for successful protection of all individuals against toxic chemicals. This book, which is based on a WHO consultation, provides an overview of current knowledge on genetic predisposition to chemical toxicity. It reviews the experimental, pharmacological, toxicogenetic and epidemiological evidence and considers the implications for preventative action and future research. The important ethical and legal aspects are covered, as is the importance of genetic factors in the pathogenesis of ischaemic heart disease and major types of cancer. Written and edited by an international team of experts, this book should be a vital reference source for industrial and environmental health officers, health care planners and physicians and researchers in toxicology, pharmacology, genetics, clinical chemistry, epidemiology and occupational health.

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