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Comparative Genomics - Empirical and Analytical Approaches to Gene Order Dynamics, Map Alignment and the Evolution of Gene Families (Computational Biology)



Rok: 2000
ISBN: 9780792365846
OKCZID: 110069349


Anotace

 

This is the first book on comparative genomics focusing on the evolving linear structure of the genome, from organelles and prokaryotes through to the multichromosomal nuclear genomes of plants and animals, based on modern genome map and sequence data. It is also the first collection to bring together the diverse range of combinatorial optimization and probabilistic modeling techniques for analyzing genome rearrangements in the context of clinical cytogenetics, molecular genetics, population biology, microbial genomics, and the domesticated plant and animal genome projects. It critically compares functional and neutral conceptions of genome rearrangement and represents a concerted attack on the modeling and analytical problems associated with gene and genome duplication and with multigene families. The comprehensive interdisciplinarity of this work and the stature of the biological and mathematical scientists who have contributed to it make it an invaluable resource for courses on genomics or computational biology, and an indispensable reference work for geneticists, molecular biologists, and bioinformaticians in the post-genomic era.


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