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Drug-Drug Interactions, Second Edition (Drugs and the Pharmaceutical Sciences)
Rok: 2007
ISBN: 9780849375934
NKP-CNB: boa001-muni.000602528
OKCZID: 110316723
Citace (dle ČSN ISO 690):
RODRIGUES, A. David, ed. Drug-drug interactions. 2nd ed. New York: Informa Healthcare, c2008. xi, 744 s. Drugs and the pharmaceutical sciences, vol. 179.
Anotace
Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives. Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on: key interplay between transporters and enzymes in drug metabolism and drug interactions the integral role of pharmacogenetics in metabolism-based drug-drug interactions in vivo – in vitro correlations (reversible, mechanism-based inhibition, induction) in silico approaches enabling structure-activity and structure-function studies high-throughput screening and GLP methods for evaluating drug interactions in vitro the use of transgenic animal models to evaluate drug interactions Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.