Jaffe, Elaine Sarkin

Autor: Jaffe, Elaine Sarkin
Rok: 1943-

Biogr./Hist. údaje: Americká lékařka, hematopatoložka.
Zdroj: Autoritní databáze Národní knihovny ČR

Elain Sarkin Jaffe is a senior National Cancer Institute (NCI) investigator at the National Institutes of Health (NIH). She completed her medical education at Cornell University and the University of Pennsylvania, receiving her M.D. from University of Pennsylvania in 1969. After an internship at Georgetown University she joined NCI as a resident anatomic pathology, and has been a senior investigator since 1974, focusing on the classification and definition of lymphoid neoplasms. Jaffe's early work helped to provide a much more depth understanding of the origin of lymphomas, particular her work in follicular lymphomas. Her team notably elucidated the difference between T cell and B cell lymphomas.Her lab's findings led to the development of the WHO Classification of Tumours of the Hematopoetic and Lymphoid Tissues. Jaffe was the President of the Society of Hematopathology at the time that the WHO's Revised European-American Classification of Lymphoid Neoplasms (REAL) classification system was developed in 1994; the REAL classification system is now considered the gold standard in hematopathology. Today, her research includes genetic and epigenetic studies aimed at understanding how B-cells become Hodgkins lymphoma cells, particularly through the lens of the microenvironment. Jaffe's research has led to improvements in cancer treatments, including disease-specific therapies and improved clinical outcomes.